From AppleGamingWiki, the wiki about gaming on M1 Apple silicon Macs
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Graphics settings must be set to Ultra, played in windowed mode.[3] Won't load.[4]. Cracked version framerate is low.[5]
Availability
See PCGamingWiki for Windows and/or Linux availability.
Gameplay videos
CrossOver
CrossOver issues unresolved
VATS isn't working correctly: chances to hit near 0% or 1% most of the time.
Various render glitches: mostly seen in vegetation and plants represented in the game and also broken light effects. These render glitches are not preventing the game to be played fully though, they're just annoying glitches here and there. (Jun 2023: transparency issue was fixed in the latest Crossover / Wineskin versions)
Prone to crash: often times, audio will start to fail progressively after running the game for a while. first NPC talks connot be heard anymore, then other audio problem will follow thus rendering some areas of the game impossible to pass through. Fix is easy enough: quit and relaunch the game.